Pharmacologic Treatment of Chronic Pain

Updated: May 25th, 2025

Published: May 24th, 2025

Presentation Synopsis

This educational presentation by the Opioid Remediation Collaborative (ORCNM) provides an in-depth overview of pharmacologic strategies for managing chronic pain. It explores various medication categories, clinical considerations, and non-opioid alternatives to support safe, effective, and individualized care. The presentation aims to promote awareness of best practices in prescribing, minimize risk, and advance function-focused treatment approaches in pain management.

Learning Objectives

  • Identify the major categories of pharmacologic treatments for chronic pain and understand their general mechanisms of action.

  • Explain key clinical considerations when prescribing medications, including patient history, diagnostic tools, and drug-drug interactions.

  • Evaluate non-opioid pharmacologic options and understand their role in a multimodal approach to pain management.

  • Understand the risks and side effects associated with long-term use of opioids, including tolerance, addiction, and functional decline.

  • Recognize the importance of urine drug testing and pharmacologic agreements in monitoring safety and compliance.

  • Learn principles of opioid conversion and dosing, including oral morphine equivalence and incomplete cross-tolerance.

  • Identify common medication interactions (e.g., NSAIDs with anticoagulants) and assess risks for patients with renal or liver impairment.

  • Emphasize the need for individualized, function-centered care plans that prioritize quality of life and reduce harm.

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